Novel tricyclic compounds as inhibitors of mutant idh enzymes

Composés tricycliques innovants tels que des inhibiteurs d'enzymes idh mutantes

Abstract

La présente invention concerne des composés tricycliques de formule (I), (Ia), ou (Ib) qui sont des inhibiteurs d'une ou plusieurs enzymes IDH mutantes. La présente invention concerne également des utilisations de ces composés pour la prévention ou le traitement potentiels de cancers dans lesquels une ou plusieurs enzymes IDH mutantes sont impliquées. La présente invention concerne aussi des compositions contenant ces composés. La présente invention concerne également des utilisations de ces compositions pour la prévention ou le traitement potentiels de tels cancers.
The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present invention is also directed to uses of these tricyclic compounds in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

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